Download Aging and the heart : a post-genomic view by José Marín-García; Michael J Goldenthal; Gordon W Moe PDF

By José Marín-García; Michael J Goldenthal; Gordon W Moe

ISBN-10: 0387740716

ISBN-13: 9780387740713

ISBN-10: 0387740724

ISBN-13: 9780387740720

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Drosophila dFOXO controls life span and regulates insulin signalling in brain and fat body. Nature 2004;429:562–566 44. Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999;13:2570–2580 45. Sinclair D, Guarente L. Extrachromosomal rDNA circles – a cause of aging in yeast. Cell 1997;91:1033–1042 46. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends life span in C. elegans.

Fungal Genet Biol 1999;27:26–35 38. Lorin S, Dufour A, Sainsard A. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. Biochim Biophys Acta 2006:1757:604–610 28 Post-Genomic View of Aging: Definitions, Theories and Observations 39. Morrow G, Samson M, Michaud S, Tanguay RM. Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. FASEB J 2004;18:598–599 40. Morrow G, Battistini S, Zhang P, Tanguay RM.

Also shown are antioxidant factors in peroxisomes (catalase), mitochondria (GPx, GSH and MnSOD) and in the cytosol (CuSOD), which function to scavenge ROS and reduce their impact. increased life span [106]. This can be explained if radiation exposure produces a stable activation of cellular defenses [67]. Similarly caloric restriction (CR), which can be viewed as another form of moderate stress conditioning, can prolong the life span of almost every organism in which it has been used. Considerable evidence has shown that dietary restriction including reduction in caloric intake impacts cellular metabolism including redox remodeling, reducing ROS production and upregulating antioxidant defenses [107].

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