Download Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe PDF

By Mancia Giuseppe

ISBN-10: 1841845795

ISBN-13: 9781841845791

When you consider that angiotensin II is likely one of the so much powerful vasoconstrictors and a tremendous stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a vital step in regulating blood strain. This category of drug is well-tolerated by way of pateints and those medicines have the additional virtue over ACE inhibitors in that they're no longer linked to cough. simply because so much medicines could be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive influence together with diuretics, they're a welcome healing software within the therapy of high blood pressure. This moment variation builds at the luck of the 1st and brings to the reader all of the most recent advancements, scientific trial information, and the contributors's own views whilst treating sufferers with angiotensin II receptors antagonists.

  • offers chapters through recognized members within the fields of either high blood pressure and center failure, specially with reference to pharmacological interventions
  • covers the hot position of AIIR in neuroprotection
  • builds upon the strengths of the 1st edition
  • Show description

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    J Biol Chem 1990; 265:22348–57. 5. Kleinert HD. Renin inhibition. Cardiovasc Drugs Ther 1995; 9:645–55. 6. Gradman AH, Schmeider PR, Lins RL et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005; 111:1012–18. 7. Streeten DHP. Outpatient experience with saralasin. Kidney Int 1979; 159(Suppl 9):44–52. 8. Timmermans PB, Wong PC, Chiu AT et al. Angiotensin II receptors and angiotensin II receptor antagonists.

    Kidney Int 1979; 159(Suppl 9):44–52. 8. Timmermans PB, Wong PC, Chiu AT et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993; 45:205–51. 9. Johnston CI, Naitoh M, Burrell LM. Rationale and pharmacology of angiotensin II-receptor antagonists: current status and future issues. J Hypertens 1997; 15(Suppl 8):3–6. 10. Unger T, Culman J, Gohlke P. Angiotensin II-receptor blockade and end-organ protection: pharmacological rationale and evidence. J Hypertens 1998; 16(Suppl 7):3–9.

    44. Markham A, Goa KL. Valsartan. A review of its pharmacology and therapeutic use in essential hypertension. Drugs 1997; 54:299–331. 45. Weber AM. Angiotensin II receptor blockers and cardiovascular outcomes: what does the future hold? J Renin Eng Ald Syst 2003; 4:62–73. 556 7/3/06 4:06 pm Page 31 Stimulation of AT2 receptors: role in the effect of angiotensin II receptor antagonists 3 Heiko Funke-Kaiser, Ulrike Muscha Steckelings, and Thomas Unger Introduction This chapter will focus on the hypothesis that angiotensin AT1 receptor blockers (ARBs) act not only by blocking the deleterious effects of angiotensin II type 1 receptor (AT1R) activation but also by indirectly activating the angiotensin II type 2 receptor (AT2R).

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